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1 in 16 women take harmful medications while pregnant

Justin Rowell by Justin Rowell
29.09.2022
Home Science

A pregnant woman holds a pill in one hand and a glass of water in the other while sitting on a bed

One in 16 pregnant women take harmful teratogenic drugs, a review of more than 3 million pregnancies shows.

Teratogenic drugs can cause pregnancy loss, birth defects, and other health problems for the unborn child.

The new findings highlight the need for women and their providers to carefully examine medications taken during pregnancy.

“If you are pregnant, planning to become pregnant, or sexually active you must understand the risks involved with taking teratogenic drugs,” says study author Almut Winterstein, professor and chair of the department of pharmaceutical outcomes and policy in the University of Florida College of Pharmacy, part of University of Florida Health.

“Talk with your provider about your medications and review drug labels to ensure the medications you are taking are not putting your unborn child at risk,” says Winterstein, who also directs the Center for Drug Evaluation and Safety.

A teratogen is a substance that interferes with the normal development of a fetus. Hundreds of such drugs have been identified, including medications to treat seizures, migraines, obesity, acne, hypertension, bipolar disease, and cancer.

For the study in the American Journal of Obstetrics and Gynecology, the researchers investigated more than 200 teratogenic drugs and evaluated their exposure among 3.4 million pregnancies identified in a national private insurance database from 2006 to 2017. Prenatal exposure was defined by the mother taking at least one teratogenic drug during pregnancy.

Using teratology drug databases, the medications were separated into two classes based upon their known teratogenic effect. About 140 drugs were known to have definite teratogenic effects, and another 65 were identified as having potential teratogenic effects.

The proportion of pregnancies with exposure to definite teratogens decreased slightly over the 12-year study period from 1.9% to 1.2%, while exposures for potential teratogens increased from 3.4% to 5.3%.

“While declining exposure rates among teratogenic drugs with definite risk are encouraging, the rising prenatal exposure to drugs with potential risk calls for more assessment,” Winterstein says. “To have 1 in 16 women and their unborn baby exposed to a teratogenic medication is simply too high, and we must identify strategies to improve pregnancy outcomes.”

The researchers also examined age and risk for prenatal exposure to teratogenic drugs and found teenagers and women in their 40s had the greatest risk. Winterstein says both of these groups are known to have more unintended pregnancies and the drug exposure may have been accidental, which points to the need for more information about effective birth control and family planning when using teratogenic drugs.

The researchers were particularly interested in prenatal exposure during more recent years, following the enactment of the FDA Amendment Act of 2007. That legislation allowed the US Food and Drug Administration to require drug manufacturers to implement a risk evaluation and mitigation strategy for certain medications with serious safety concerns.

Those mitigation strategies are designed to reinforce safe medication-use behaviors, such as a pregnancy test before a teratogenic drug is started. Only a few medications require this extra safety precaution.

The researchers found the 12 drugs with mitigation protocols in the study to be used infrequently and contributed to only a small portion of prenatal exposures. The study’s authors conclude more research and regulatory action are needed to optimize the use of medications during pregnancy.

“There is much to do to address the evidence available regarding the risk-benefit of many drugs during pregnancy, and the availability of adequate risk-mitigation programs that ensure pregnancies are not unnecessarily exposed to teratogenic drugs,” Winterstein says.

“In the meantime, women and their providers must rely on the written information that is provided about the teratogenic risk for drugs during pregnancy.”

Source: University of Florida

The post 1 in 16 women take harmful medications while pregnant appeared first on Technovanguard.


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