• Home
  • About
  • Contact us
  • Submit a News Releases
Tech News, Magazine & Review WordPress Theme 2017
  • Computing
  • Entertainment
  • Gaming
  • Mobile
  • Science
  • Security
  • Services
  • Software
  • Space
No Result
View All Result
  • Computing
  • Entertainment
  • Gaming
  • Mobile
  • Science
  • Security
  • Services
  • Software
  • Space
Technovanguard — Be at the forefront of technology news
No Result
View All Result

Unboosted cancer patients with breakthrough COVID face high death risk

Justin Rowell by Justin Rowell
10.01.2022
Home Science

An older woman gets a vaccine while wearing a yellow medical mask

Vaccinated (but not boosted) people with cancer who have breakthrough COVID-19 infections remain at high risk for hospitalization and death, according to a new study.

The findings show that vaccinated patients who experienced breakthrough COVID-19 infections had a hospitalization rate of 65%, an ICU or mechanical ventilation rate of 19%, and a 13% death rate.

Researchers collected data for the study before booster vaccines were recommendation for patients with cancer by the US Centers for Disease Control and Prevention.

“These findings come at a time of concerns that immune escape mutants such as the Omicron strain may emerge from chronically infected patients with weakened immune systems,” says Dimitrios Farmakiotis, an associate professor of medicine at Brown University’s Warren Alpert Medical School and a senior author of the study in Annals of Oncology.

“Thus, the immunosuppressed and their close contacts should be target groups for therapeutic and preventive interventions, including community-level outreach and educational efforts.”

The COVID-19 and Cancer Consortium, a group of 129 research centers that is tracking the impact of COVID-19 on patients with cancer, conducted the study. The Lifespan Cancer Institute and partner Brown University are among the participating institutions.

Similar high COVID-19 mortality rates among fully vaccinated individuals have been reported in other immunocompromised patient populations, such as organ transplant recipients, prior to the utilization of additional vaccine doses, Farmakiotis says.

At the time the study was conducted, patients were considered fully vaccinated after having received two doses of either the Pfizer-BioNTech vaccine or the Moderna vaccine, or one dose of the Johnson & Johnson vaccine, with the last dose long enough before breakthrough COVID-19 to consider them fully vaccinated.

Researchers collected the data from November 2020 through May 2021, before booster vaccines were recommended by the CDC.

The consortium identified 1,787 patients with cancer and COVID-19 for the study, the vast majority of which were unvaccinated. The number of fully vaccinated was 54, and 46% of those fully vaccinated had reduced levels of lymphocytes—the T cells and B cells responsible for immunological responses to viruses. Lymphopenia commonly occurs in patients with cancer receiving anti-CD20 monoclonal antibodies or CAR-T-cell treatments for hematologic malignancies, including lymphoma and leukemia.

The study appears to support previous observations that patients with hematologic malignancies are at greater risk for severe outcomes from COVID-19. However, the number of patients in the study is too small to make definitive conclusions about specific types of anticancer therapies that might be associated with breakthrough infections, the researchers note. Patients on a treatment regimen of corticosteroids also appeared to be more susceptible to hospitalization.

“Because measures of immunity are not routinely collected in clinical care, we don’t know whether these were patients who mounted effective immune responses after vaccination; a lot of emerging data have suggested that patients with cancer, especially blood cancers, don’t mount adequate protective antibody responses,” says Jeremy Warner, director of the CCC19 Research Coordinating Center, associate professor at Vanderbilt-Ingram Cancer Center, and a senior author of the study.

“It’s important to note that many of the same factors that we identified prior to the availability of vaccination—age, comorbidities, performance status, and progressing cancer—still seem to drive many of the bad outcomes.”

Farmakiotis is also director of transplant and oncology infectious diseases at Rhode Island Hospital, the Lifespan Cancer Institute, and the Lifespan Cardiovascular Institute.

Additional coauthors are from Dana-Farber Cancer Institute, Vanderbilt-University Medical Center, and Brown.

Source: Brown University

The post Unboosted cancer patients with breakthrough COVID face high death risk appeared first on Technovanguard.


Next Post
The Uncertain Future of Antarctica’s Melting Ice

The Uncertain Future of Antarctica’s Melting Ice

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recommended.

Aya Neo NEXT : la future console PC mobile AMD

Aya Neo NEXT : la future console PC mobile AMD

25.12.2021
Tip: All Simple Mobile Tools Android apps are free on Google Play currently

Tip: All Simple Mobile Tools Android apps are free on Google Play currently

25.12.2021

Trending.

LANL Publishes Guide to Quantum Computer Programming

LANL Publishes Guide to Quantum Computer Programming

15.06.2022
A Global Ocean Biogeochemical Observatory Becomes a Reality

A Global Ocean Biogeochemical Observatory Becomes a Reality

21.03.2022
ROCK5 Model B : une carte de dev sous RK3588

ROCK5 Model B : une carte de dev sous RK3588

13.01.2022
7 Essentials You Need to Complete Your Twitch Streaming Setup

7 Essentials You Need to Complete Your Twitch Streaming Setup

15.12.2021
XT-ZB1 DevKit : un module Zigbee et Bluetooth RISC-V à 2€

XT-ZB1 DevKit : un module Zigbee et Bluetooth RISC-V à 2€

27.12.2021
Technovanguard — Be at the forefront of technology news

Technovanguard - The latest news from the world of IT and modern technologies.

Categories

  • Computing
  • Entertainment
  • Gaming
  • Mobile
  • Science
  • Security
  • Services
  • Software
  • Space
  • Без рубрики

Tags

FEATUREDNEWS

Recent News

Tech giants form Metaverse Standards Forum to promote collaboration

Tech giants form Metaverse Standards Forum to promote collaboration

26.06.2022
The Umbrella Academy cast shares their favorite group scenes from season 3

The Umbrella Academy cast shares their favorite group scenes from season 3

26.06.2022
  • Home
  • About
  • Contact us
  • Submit a News Releases

© 2021 technovanguard.com.

No Result
View All Result
  • Computing
  • Entertainment
  • Gaming
  • Mobile
  • Science
  • Security
  • Services
  • Software
  • Space

© 2021 technovanguard.com.